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Author(s):
Ceyhan, G. O.; Timm, A.-K.; Bergmann, F.; Günther, A.; Aghdassi, A. A.; Demir, I. E.; Mayerle, J.; Kern, M.; Lerch, M. M.; Büchler, M. W.; Friess, H.; Schemmer, P. 
Title:
Prophylactic Glycine Administration Attenuates Pancreatic Damage and Inflammation in Experimental Acute Pancreatitis 
Abstract:
Background/Aims: Acute pancreatitis (AP) is characterized by premature zymogen activation, systemic inflammatory response resulting in inflammatory infiltrates, sustained intracellular calcium, neurogenic inflammation and pain. The inhibitory neurotransmitter and cytoprotective amino acid glycine exerts a direct inhibitory effect on inflammatory cells, inhibits calcium influx and neuronal activation and therefore represents a putative therapeutic agent in AP. Methods: To explore the impact of gl...    »
 
Keywords:
Glycine; Acute pancreatitis; Cerulein; Taurocholate 
Journal title:
Pancreatology 
Year:
2011 
Journal volume:
11 
Journal issue:
Pages contribution:
57--67 
Fulltext / DOI:
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
14243903 
E-ISSN:
1424-3911 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.