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Autor(en):
Rusai, Krisztina; Wagner, Bettina; Roos, Marcel; Schmaderer, Christoph; Strobl, Matthias; Boini, Krishna M.; Grenz, Almut; Kuhl, Dietmar; Heemann, Uwe; Lang, Florian; Lutz, Jens 
Titel:
The Serum and Glucocorticoid-Regulated Kinase 1 in Hypoxic Renal Injury 
Abstract:
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein kinase activated through the phosphatidylinositol 3-kinase (PI3-kinase) pathway and counteracting apoptosis. Protein expression and activation of SGK1 are increased in various models of cell stress. The present study explored the role of SGK1 in renal hypoxia/ischemia induced apoptosis. HEK 293 cells were exposed in vitro to hypoxia/reoxygenation (H/R), which increased SGK1 transcript levels, SGK1 protein abund...    »
 
Stichworte:
Apoptosis; Hypoxia; Ischemia/reperfusion; Kidney; SGK1 
Zeitschriftentitel:
Cellular Physiology and Biochemistry 
Jahr:
2009 
Band / Volume:
24 
Heft / Issue:
5-6 
Seitenangaben Beitrag:
577--584 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1421-9778 
E-ISSN:
1421-9778 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.