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Autor(en):
Wagenlehner, Florian M.E.; Wagenlehner, Christine M.; Blenk, Birgit; Blenk, Holger; Schubert, Sabine; Dalhoff, Axel; Naber, Kurt G. 
Titel:
Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose 
Abstract:
Background: Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. Methods: Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a reference strain and 9 selected clinical uropathogens at the pH of native, acidified (pH 5.5) and alkalinized (pH 8.0) urine. Results: The mean maximum urine concentrations for 200 and 80...    »
 
Stichworte:
Finafloxacin; Urine pharmacokinetics; Pharmacodynamics; Urinary bactericidal titers 
Zeitschriftentitel:
Chemotherapy 
Jahr:
2011 
Band / Volume:
57 
Heft / Issue:
Seitenangaben Beitrag:
97--107 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1421-9794 
E-ISSN:
1421-9794 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.