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Autor(en):
Witt, Heiko 
Titel:
Genetics of Pancreatitis: A Guide for Clinicians 
Abstract:
It is now generally believed that pancreatitis results from pancreatic autodigestion. An inappropriate conversion of pancreatic zymogens to active enzymes within the pancreatic parenchyma is thought to initiate the inflammatory process. A key role has been attributed to the activation of trypsinogen to trypsin, converting all proteolytic proenzymes to their active form. Several gain-of-function mutations in the cationic trypsinogen gene (PRSS1) have been identified in patients with chronic pancr...    »
 
Stichworte:
Chronic pancreatitis; Genetics; CTRC; CFTR; PRSS1; PRSS2; SPINK1 
Zeitschriftentitel:
Digestive Diseases 
Jahr:
2010 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
702--708 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1421-9875 
E-ISSN:
1421-9875 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.