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Author(s):
Witt, Heiko 
Title:
Genetics of Pancreatitis: A Guide for Clinicians 
Abstract:
It is now generally believed that pancreatitis results from pancreatic autodigestion. An inappropriate conversion of pancreatic zymogens to active enzymes within the pancreatic parenchyma is thought to initiate the inflammatory process. A key role has been attributed to the activation of trypsinogen to trypsin, converting all proteolytic proenzymes to their active form. Several gain-of-function mutations in the cationic trypsinogen gene (PRSS1) have been identified in patients with chronic pancr...    »
 
Keywords:
Chronic pancreatitis; Genetics; CTRC; CFTR; PRSS1; PRSS2; SPINK1 
Journal title:
Digestive Diseases 
Year:
2010 
Journal volume:
28 
Journal issue:
Pages contribution:
702--708 
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
1421-9875 
E-ISSN:
1421-9875 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.