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Author(s):
Ströhlein, Michael A.; Lordick, Florian; Rüttinger, Dominik; Grützner, Klaus-Uwe; Schemanski, Oliver C.; Jäger, Michael; Lindhofer, Horst; Hennig, Michael; Jauch, Karl-Walter; Peschel, Christian; Heiss, Markus M. 
Title:
Immunotherapy of Peritoneal Carcinomatosis with the Antibody Catumaxomab in Colon, Gastric, or Pancreatic Cancer: An Open-Label, Multicenter, Phase I/II Trial 
Abstract:
Background: Peritoneal carcinomatosis (PC) is common in gastrointestinal (GI) cancer and there is no effective standard treatment. We investigated the tolerability and maximum tolerated dose (MTD) of the trifunctional antibody catumaxomab in patients with PC. Methods: In this openlabel, phase I/II clinical trial, patients with epithelial cell adhesion molecule (EpCAM)-positive PC from GI cancer received 4 sequential intraperitoneal catumaxomab infusions: day 0: 10 µg; day 3: 10 or 20 µg; day 7...    »
 
Keywords:
Epithelial cell adhesion molecule (EpCAM); Catumaxomab; Antibody, trifunctional; Immunotherapy; Peritoneal carcinomatosis 
Journal title:
Onkologie 
Year:
2011 
Journal volume:
34 
Journal issue:
Pages contribution:
101--108 
Publisher:
S. Karger GmbH 
Publisher address:
Freiburg, Germany 
Print-ISSN:
1423-0240 
E-ISSN:
2296-5262 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.