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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Tando, Yusuke; Algül, Hana; Schneider, Günter; Weber, Christoph K.; Weidenbach, Hans; Adler, Guido; Schmid, Roland M. 
Titel:
Induction of ItextgreekkB-Kinase by Cholecystokinin Is Mediated by Trypsinogen Activation in Rat Pancreatic Lobules 
Abstract:
Background and Aims: Supramaximal concentrations of cholecystokinin (CCK) or cerulein induce the intracellular activation of trypsinogen and the transcription factor NF-ĸB, a key regulator of inflammatory gene expression. Both events occur early in the development of an acute pancreatitis. The aim of this study was to examine the relationship between intracellular trypsinogen and NF-ĸB activation. Methods: We detected NF-ĸB-binding activity in electromobility shift assays, IĸB proteolysis in Wes...    »
 
Stichworte:
NF-κ B; Iκ B-kinase; Trypsinogen; Trypsin activation; Acute pancreatitis; Concentrations of cholecystokinin; Serine protease inhibitor 
Zeitschriftentitel:
Digestion 
Jahr:
2002 
Band / Volume:
66 
Heft / Issue:
Seitenangaben Beitrag:
237--245 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1421-9867 
E-ISSN:
1421-9867 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.