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Autor(en):
Mascetta, G.; Di Mola, F. F.; Tavano, F.; Selvaggi, F.; Giese, N.; Bassi, C.; Büchler, M. W.; Friess, H.; Di Sebastiano, P. 
Titel:
Substance P and Neprilysin in Chronic Pancreatitis 
Abstract:
Background/Aims: We aimed to analyze substance P (SP) and neprilysin (NEP), the membrane metallopeptidase that degrades SP, in chronic pancreatitis (CP). Methods: SP and NEP mRNA levels were analyzed by qRT-PCR in tissue samples from 30 patients with CP and 8 organ donors. In addition, SP serum levels were determined before and after surgery in the same patients, by means of a competitive ELISA assay. Genetic and epigenetic analyses of the NEP gene were also performed. Results: SP mRNA expressio...    »
 
Stichworte:
Chronic pancreatitis; Neuroimmune interaction; Substance P; Neprilysin; MicroRNAs 
Zeitschriftentitel:
European Surgical Research 
Jahr:
2012 
Band / Volume:
48 
Heft / Issue:
Seitenangaben Beitrag:
131--138 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1421-9921 
E-ISSN:
1421-9921 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.