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Author(s):
Nussler, A. K.; Hao, L.; Knobeloch, D.; Yao, P.; Nussler, N. C.; Wang, Z.; Liu, L.; Ehnert, S. 
Title:
Protective Role of HO-1 for Alcohol-Dependent Liver Damage 
Abstract:
Background/Aims: Alcoholic liver disease is continuously increasing in developed countries being a leading cause of death worldwide. Chronic ethanol consumption induces oxidative stress by accumulation of reactive oxygen intermediates (ROI) while reducing the cellular antioxidant defense. Induction of heme oxygenase-1 (HO-1) may protect primary human hepatocytes (hHeps) from such damage. Thus, the aim of this study was to investigate the potential of polyphenols to protect hHeps from ethanol-dep...    »
 
Keywords:
HO-1; Hepatocytes; Quercetin; Oxidative stress 
Journal title:
Digestive Diseases 
Year:
2010 
Journal volume:
28 
Journal issue:
Pages contribution:
792--798 
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
1421-9875 
E-ISSN:
1421-9875 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.