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Document type:
journal article 
Author(s):
Wang, Kun; Demir, Ihsan Ekin; D'Haese, Jan G; Tieftrunk, Elke; Kujundzic, Kristina; Schorn, Stephan; Xing, Baocai; Kehl, Timo; Friess, Helmut; Ceyhan, Güralp O 
Title:
The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. 
Abstract:
Neurotrophic factors possess an emerging role in the pathophysiology of several gastrointestinal disorders, regulating innervation, pain sensation and disease-associated neuroplasticity. Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-derived neurotrophic factor receptor alpha-2 (GFR?-2) in pancreatic cancer (PCa) and pancreatic neuropathy. For this purpose, NRTN and GFR?-2 were studied in normal human pancreas and PCa tissue...    »
 
Journal title abbreviation:
Carcinogenesis 
Year:
2014 
Journal volume:
35 
Journal issue:
Pages contribution:
103-13 
Language:
eng 
Print-ISSN:
0143-3334 
TUM Institution:
Chirurgiesche Klinik und Poliklinik