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Dokumenttyp:
journal article 
Autor(en):
Krebs, K; Böttinger, N; Huang, LR; Chmielewski, M; Arzberger, S; Gasteiger, G; Jäger, C; Schmitt, E; Bohne, F; Aichler, M; Uckert, W; Abken, H; Heikenwalder, M; Knolle, P; Protzer, U 
Titel:
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. 
Abstract:
Antiviral agents suppress hepatitis B virus (HBV) replication but do not clear the infection. A strong effector T-cell response is required to eradicate HBV, but this does not occur in patients with chronic infection. T cells might be directed toward virus-infected cells by expressing HBV-specific receptors and thereby clear HBV and help to prevent development of liver cancer. In mice, we studied whether redirected T cells can engraft after adoptive transfer, without prior T-cell depletion, and...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2013 
Band / Volume:
145 
Heft / Issue:
Seitenangaben Beitrag:
456-65 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
Institut für Virologie; Institut für Molekulare Immunologie