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Dokumenttyp:
journal article 
Autor(en):
Huang, LR; Wohlleber, D; Reisinger, F; Jenne, CN; Cheng, RL; Abdullah, Z; Schildberg, FA; Odenthal, M; Dienes, HP; van Rooijen, N; Schmitt, E; Garbi, N; Croft, M; Kurts, C; Kubes, P; Protzer, U; Heikenwalder, M; Knolle, PA 
Titel:
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. 
Abstract:
Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs:'intrahepatic myeloid-cell aggregates for T cell population expansion') without causing immunopathology. In the liver, CTL proliferation was restricted to iMATEs that were composed of infl...    »
 
Zeitschriftentitel:
Nat Immunol 
Jahr:
2013 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
574-83 
Sprache:
eng 
Print-ISSN:
1529-2908 
TUM Einrichtung:
Institut für Virologie; Institut für Molekulare Immunologie