Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Tsolakidou, A; Alexopoulos, P; Guo, LH; Grimmer, T; Westerteicher, C; Kratzer, M; Jiang, M; Bujo, H; Roselli, F; Leante, MR; Livrea, P; Kurz, A; Perneczky, R 
Titel:
?-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau. 
Abstract:
?-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid ? production, which is a pathological hallmark of Alzheimer's disease (AD).The present study explored the correlation between BACE1 activity and cerebrospinal fluid (CSF) markers of APP metabolism and axonal degeneration in 63 patients with mild AD and 12 healthy control subjects.In the AD group, positive correlations between BACE1 activity and...    »
 
Zeitschriftentitel:
Alzheimers Dement 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
386-91 
Sprache:
eng 
Print-ISSN:
1552-5260 
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie