Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Leierseder, Simon; Petzold, Tobias; Zhang, Lin; Loyer, Xavier; Massberg, Steffen; Engelhardt, Stefan 
Titel:
MiR-223 is dispensable for platelet production and function in mice. 
Abstract:
MicroRNAs (miRNAs) are key physiological regulators in multiple cell types. Here, we assessed platelet production and function in mice deficient in miR-223, one of the most abundantly expressed miRNAs in platelets and megakaryocytes. We found platelet number, size, life-span as well as surface expression of platelet adhesion receptors to be unchanged in miR-223-deficient mice. Likewise, loss of miR-223 did not affect platelet activation, adhesion and aggregation and also had no effect on bleedin...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2013 
Band / Volume:
110 
Heft / Issue:
Seitenangaben Beitrag:
1207-14 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie