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Dokumenttyp:
journal article 
Autor(en):
Ding, Jie; Domes, Katrin; Hofmann, Franz; Wegener, Jörg W 
Titel:
Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes. 
Abstract:
Cardiac CaV1.2 channels play a critical role in cardiac function. It has been proposed that the carboxyl-terminal intracellular tail of the CaV1.2 channel is the target of Ca(2+)-dependent and Ca(2+)-independent regulation of the channel. Recent studies on C-terminal truncated forms of the CaV1.2 channel reported neonatal death, reduced CaV1.2 current, and failure of ?-adrenergic stimulation of these channels in ventricular cardiomyocytes (CMs). Here, we used atrial CMs at embryonic day 18.5 tha...    »
 
Zeitschriftentitel:
Pflugers Arch 
Jahr:
2013 
Band / Volume:
465 
Heft / Issue:
Seitenangaben Beitrag:
955-64 
Sprache:
eng 
Print-ISSN:
0031-6768 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie