Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Wincott, Charlotte M; Kim, Seonil; Titcombe, Roseann F; Tukey, David S; Girma, Hiwot K; Pick, Joseph E; Devito, Loren M; Hofmann, Franz; Hoeffer, Charles; Ziff, Edward B 
Titel:
Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice. 
Abstract:
Activity-dependent trafficking of AMPA receptors to synapses regulates synaptic strength. Activation of the NMDA receptor induces several second messenger pathways that contribute to receptor trafficking-dependent plasticity, including the NO pathway, which elevates cGMP. In turn, cGMP activates the cGMP-dependent protein kinase type II (cGKII), which phosphorylates the AMPA receptor subunit GluA1 at serine 845, a critical step facilitating synaptic delivery in the mechanism of activity-dependen...    »
 
Zeitschriftentitel:
Neurobiol Learn Mem 
Jahr:
2013 
Band / Volume:
99 
Seitenangaben Beitrag:
32-7 
Sprache:
eng 
Print-ISSN:
1074-7427 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie