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Dokumenttyp:
journal article 
Autor(en):
Cheepala, Satish; Hulot, Jean-Sebastien; Morgan, Jessica A; Sassi, Yassine; Zhang, Weiqiang; Naren, Anjaparavanda P; Schuetz, John D 
Titel:
Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters. 
Abstract:
Cyclic nucleotides [e.g., cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)] are ubiquitous second messengers that affect multiple cell functions from maturation of the egg to cell division, growth, differentiation, and death. The concentration of cAMP can be regulated by processes within membrane domains (local regulation) as well as throughout a cell (global regulation). The phosphodiesterases (PDEs) that degrade cAMP have well-known roles in both these processes....    »
 
Zeitschriftentitel:
Annu Rev Pharmacol Toxicol 
Jahr:
2013 
Band / Volume:
53 
Seitenangaben Beitrag:
231-53 
Sprache:
eng 
Print-ISSN:
0362-1642 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie