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Dokumenttyp:
journal article 
Autor(en):
Yentrapalli, R; Azimzadeh, O; Sriharshan, A; Malinowsky, K; Merl, J; Wojcik, A; Harms-Ringdahl, M; Atkinson, MJ; Becker, KF; Haghdoost, S; Tapio, S 
Titel:
The PI3K/Akt/mTOR Pathway Is Implicated in the Premature Senescence of Primary Human Endothelial Cells Exposed to Chronic Radiation. 
Abstract:
The etiology of radiation-induced cardiovascular disease (CVD) after chronic exposure to low doses of ionizing radiation is only marginally understood. We have previously shown that a chronic low-dose rate exposure (4.1 mGy/h) causes human umbilical vein endothelial cells (HUVECs) to prematurely senesce. We now show that a dose rate of 2.4 mGy/h is also able to trigger premature senescence in HUVECs, primarily indicated by a loss of growth potential and the appearance of the senescence-associate...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e70024 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie