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Dokumenttyp:
journal article 
Autor(en):
Krieg, P; Rosenberger, S; de Juanes, S; Latzko, S; Hou, J; Dick, A; Kloz, U; van der Hoeven, F; Hausser, I; Esposito, I; Rauh, M; Schneider, H 
Titel:
Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. 
Abstract:
Loss-of-function mutations in the lipoxygenase (LOX) genes ALOX12B and ALOXE3 are the second most common cause of autosomal recessive congenital ichthyosis. The encoded proteins, 12R-LOX and epidermal LOX-3 (eLOX-3), act in sequence to convert fatty acid substrates via R-hydroperoxides to specific epoxyalcohol derivatives and have been proposed to operate in the same metabolic pathway during epidermal barrier formation. Here, we show that eLOX-3 deficiency in mice results in early postnatal deat...    »
 
Zeitschriftentitel:
J Invest Dermatol 
Jahr:
2013 
Band / Volume:
133 
Heft / Issue:
Seitenangaben Beitrag:
172-80 
Sprache:
eng 
Print-ISSN:
0022-202X 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie