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Document type:
journal article 
Author(s):
Petersen, B; Wolf, M; Austermann, J; van Lent, P; Foell, D; Ahlmann, M; Kupas, V; Loser, K; Sorg, C; Roth, J; Vogl, T 
Title:
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. 
Abstract:
Mrp8 and Mrp14 are endogenous alarmins amplifying inflammation via Toll-like receptor-4 (TLR-4) activation. Due to their pro-inflammatory properties, alarmins are supposed to enhance adaptive immunity via activation of dendritic cells (DCs). In contrast, analysing a model of allergic contact dermatitis (ACD) we observed a more severe disease outcome in Mrp8/14-deficient compared to wild-type mice. This unexpected phenotype was associated with an enhanced T-cell response due to an accelerated mat...    »
 
Journal title abbreviation:
EMBO J 
Year:
2013 
Journal volume:
32 
Journal issue:
Pages contribution:
100-11 
Language:
eng 
Print-ISSN:
0261-4189 
TUM Institution:
Abteilung für Neuroradiologie