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Dokumenttyp:
journal article 
Autor(en):
Petersen, B; Wolf, M; Austermann, J; van Lent, P; Foell, D; Ahlmann, M; Kupas, V; Loser, K; Sorg, C; Roth, J; Vogl, T 
Titel:
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. 
Abstract:
Mrp8 and Mrp14 are endogenous alarmins amplifying inflammation via Toll-like receptor-4 (TLR-4) activation. Due to their pro-inflammatory properties, alarmins are supposed to enhance adaptive immunity via activation of dendritic cells (DCs). In contrast, analysing a model of allergic contact dermatitis (ACD) we observed a more severe disease outcome in Mrp8/14-deficient compared to wild-type mice. This unexpected phenotype was associated with an enhanced T-cell response due to an accelerated mat...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2013 
Band / Volume:
32 
Heft / Issue:
Seitenangaben Beitrag:
100-11 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
Abteilung für Neuroradiologie