Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Yamada, Elizabeth S; Respondek, Gesine; Müssner, Stefanie; de Andrade, Anderson; Höllerhage, Matthias; Depienne, Christel; Rastetter, Agnès; Tarze, Agathe; Friguet, Bertrand; Salama, Mohamed; Champy, Pierre; Oertel, Wolfgang H; Höglinger, Günter U 
Titel:
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. 
Abstract:
Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the tau gene have been associated with familial tauopathies, while annonacin, a plant-derived mitochondrial inhibitor, has been implicated in an environmental form of tauopathy. We therefore determined whether there was a pathogenic synergy between annonacin exposure and the expr...    »
 
Zeitschriftentitel:
Exp Neurol 
Jahr:
2014 
Band / Volume:
253 
Seitenangaben Beitrag:
113-25 
Sprache:
eng 
Print-ISSN:
0014-4886 
TUM Einrichtung:
Neurologische Klinik und Poliklinik