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Dokumenttyp:
journal article 
Autor(en):
Ellinghaus, D; Baurecht, H; Esparza-Gordillo, J; Rodríguez, E; Matanovic, A; Marenholz, I; Hübner, N; Schaarschmidt, H; Novak, N; Michel, S; Maintz, L; Werfel, T; Meyer-Hoffert, U; Hotze, M; Prokisch, H; Heim, K; Herder, C; Hirota, T; Tamari, M; Kubo, M; Takahashi, A; Nakamura, Y; Tsoi, LC; Stuart, P; Elder, JT; Sun, L; Zuo, X; Yang, S; Zhang, X; Hoffmann, P; Nöthen, MM; Fölster-Holst, R; Winkelmann, J; Illig, T; Boehm, BO; Duerr, RH; Büning, C; Brand, S; Glas, J; McAleer, MA; Fahy, CM; Kabesch,...    »
 
Titel:
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. 
Abstract:
Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency. To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals wi...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2013 
Band / Volume:
45 
Heft / Issue:
Seitenangaben Beitrag:
808-12 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
Neurologische Klinik und Poliklinik