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Dokumenttyp:
journal article 
Autor(en):
Buck, D; Albrecht, E; Aslam, M; Goris, A; Hauenstein, N; Jochim, A; International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium; Cepok, S; Grummel, V; Dubois, B; Berthele, A; Lichtner, P; Gieger, C; Winkelmann, J; Hemmer, B 
Titel:
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. 
Abstract:
Intrathecal synthesis of immunoglobulin gamma (IgG) synthesis is frequently observed in patients with multiple sclerosis (MS). Whereas the extent of intrathecal IgG synthesis varies largely between patients, it remains rather constant in the individual patient over time. The aim of this study was to identify common genetic variants associated with the IgG index as a marker of intrathecal IgG synthesis in MS.We performed a genome-wide association study of the IgG index in a discovery series of 22...    »
 
Zeitschriftentitel:
Ann Neurol 
Jahr:
2013 
Band / Volume:
73 
Heft / Issue:
Seitenangaben Beitrag:
86-94 
Sprache:
eng 
Print-ISSN:
0364-5134 
TUM Einrichtung:
Neurologische Klinik und Poliklinik