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Document type:
journal article 
Author(s):
Holzscheiter, M; Layland, L E; Loffredo-Verde, E; Mair, K; Vogelmann, R; Langer, R; Wagner, H; Prazeres da Costa, C 
Title:
Lack of host gut microbiota alters immune responses and intestinal granuloma formation during schistosomiasis. 
Abstract:
Fatalities from schistosome infections arise due to granulomatous, immune-mediated responses to eggs that become trapped in host tissues. Schistosome-specific immune responses are characterized by initial T helper type 1 (Th1) responses and our previous studies demonstrated that myeloid differentiation primary response gene 88 (Myd88)-deficient mice failed to initiate such responses in vivo. Paradoxically, schistosomal antigens fail to stimulate innate cells to release proinflammatory cytokines...    »
 
Journal title abbreviation:
Clin Exp Immunol 
Year:
2014 
Journal volume:
175 
Journal issue:
Pages contribution:
246-57 
Language:
eng 
Print-ISSN:
0009-9104 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene