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Document type:
journal article 
Author(s):
Turqueti-Neves, Adriana; Otte, Manuel; Prazeres da Costa, Olivia; Höpken, Uta E; Lipp, Martin; Buch, Thorsten; Voehringer, David 
Title:
B-cell-intrinsic STAT6 signaling controls germinal center formation. 
Abstract:
Infection with helminths and exposure to antigens induce a strong type 2 immune response resulting in the secretion of the cytokines IL-4 and IL-13 by CD4(+) T cells and several innate cell types. IL-4 and IL-13 promote class switch recombination to IgG1 and IgE while their role for germinal center (GC) formation is poorly understood. We found a dramatic reduction in the numbers of GC B cells when investigating different type 2 immune responses in IL-4/IL-13-deficient mice. IL-4/IL-13 from T cel...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2014 
Journal volume:
44 
Journal issue:
Pages contribution:
2130-8 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene