User: Guest  Login
Document type:
journal article 
Author(s):
Stemberger, Christian; Graef, Patricia; Odendahl, Marcus; Albrecht, Julia; Dössinger, Georg; Anderl, Florian; Buchholz, Veit R; Gasteiger, Georg; Schiemann, Matthias; Grigoleit, Götz U; Schuster, Friedhelm R; Borkhardt, Arndt; Versluys, Birgitta; Tonn, Torsten; Seifried, Erhard; Einsele, Hermann; Germeroth, Lothar; Busch, Dirk H; Neuenhahn, Michael 
Title:
Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy. 
Abstract:
Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are threatened by potentially lethal viral manifestations like cytomegalovirus (CMV) reactivation. Because the success of today's virostatic treatment is limited by side effects and resistance development, adoptive transfer of virus-specific memory T cells derived from the stem cell donor has been proposed as an alternative therapeutic strategy. In this context, dose minimization of adoptively transferred T cells...    »
 
Journal title abbreviation:
Blood 
Year:
2014 
Journal volume:
124 
Journal issue:
Pages contribution:
628-37 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene