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Document type:
journal article 
Author(s):
Sledzi?ska, Anna; Fairbairn, Lynsey; Buch, Thorsten 
Title:
Manipulation of T cell function and conditional gene targeting in T cells. 
Abstract:
Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out modification at specific sites in the DNA of cells. The system consists of an enzyme, Cre recombinase, that recombines a pair of short target sequences, the lox sites. The Cre-Lox system can be used to activate or repress a gene depending on the placement of the lox sites. Placing the Cre recombinase under the control of a cell-specific promoter allows expression only in specific cells or ce...    »
 
Journal title abbreviation:
Methods Mol Biol 
Year:
2014 
Journal volume:
1193 
Pages contribution:
153-69 
Language:
eng 
Print-ISSN:
1064-3745 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene