Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Kemter, Elisabeth; Prückl, Petra; Rathkolb, Birgit; Micklich, Kateryna; Adler, Thure; Becker, Lore; Beckers, Johannes; Busch, Dirk H; Götz, Alexander A; Hans, Wolfgang; Horsch, Marion; Ivandic, Boris; Klingenspor, Martin; Klopstock, Thomas; Rozman, Jan; Schrewe, Anja; Schulz, Holger; Fuchs, Helmut; Gailus-Durner, Valérie; Hrabé de Angelis, Martin; Wolf, Eckhard; Aigner, Bernhard 
Titel:
Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. 
Abstract:
Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved. It is often characterized by hyperuricemia, gout, alteration of urine concentrating ability, as well as a variable rate of disease progression inconstantly leading to renal failure and histological alterations of the kidneys. We recently established the two Umod mutant mouse lines Umod(C93F) and Umod(A2...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2013 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
e78337 
Sprache:
eng 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene