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Document type:
journal article 
Author(s):
Kowalska, E; Ripperger, JA; Hoegger, DC; Bruegger, P; Buch, T; Birchler, T; Mueller, A; Albrecht, U; Contaldo, C; Brown, SA 
Title:
NONO couples the circadian clock to the cell cycle. 
Abstract:
Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for wound healing in mice. Specifically, although fibroblasts from NONO-deficient mice showed approximately norm...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2013 
Journal volume:
110 
Journal issue:
Pages contribution:
1592-9 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene