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Dokumenttyp:
journal article 
Autor(en):
Dössinger, G; Bunse, M; Bet, J; Albrecht, J; Paszkiewicz, PJ; Weißbrich, B; Schiedewitz, I; Henkel, L; Schiemann, M; Neuenhahn, M; Uckert, W; Busch, DH 
Titel:
MHC Multimer-Guided and Cell Culture-Independent Isolation of Functional T Cell Receptors from Single Cells Facilitates TCR Identification for Immunotherapy. 
Abstract:
Adoptive therapy using T cells redirected to target tumor- or infection-associated antigens is a promising strategy that has curative potential and broad applicability. In order to accelerate the screening process for suitable antigen-specific T cell receptors (TCRs), we developed a new approach circumventing conventional in vitro expansion-based strategies. Direct isolation of paired full-length TCR sequences from non-expanded antigen-specific T cells was achieved by the establishment of a high...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e61384 
Sprache:
eng 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene