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Document type:
journal article 
Author(s):
Reardon, C; Duncan, GS; Brüstle, A; Brenner, D; Tusche, MW; Olofsson, P; Rosas-Ballina, M; Tracey, KJ; Mak, TW 
Title:
Lymphocyte-derived ACh regulates local innate but not adaptive immunity. 
Abstract:
Appropriate control of immune responses is a critical determinant of health. Here, we show that choline acetyltransferase (ChAT) is expressed and ACh is produced by B cells and other immune cells that have an impact on innate immunity. ChAT expression occurs in mucosal-associated lymph tissue, subsequent to microbial colonization, and is reduced by antibiotic treatment. MyD88-dependent Toll-like receptor up-regulates ChAT in a transient manner. Unlike the previously described CD4(+) T-cell popul...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2013 
Journal volume:
110 
Journal issue:
Pages contribution:
1410-5 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie