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Dokumenttyp:
journal article 
Autor(en):
Poos, Kathrin; Smida, Jan; Nathrath, Michaela; Maugg, Doris; Baumhoer, Daniel; Korsching, Eberhard 
Titel:
How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation. 
Abstract:
Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affect the expression and function of several genes due to drastic changes in the underlying gene regulatory network. However, we know little about critical gene regulators and their functional consequences on the pathogenesis of OS. Therefore, we aimed to determine microRNA and transcription factor (TF) co-regulatory networks in OS cell proliferation. Cell proliferation is an essential part in the pat...    »
 
Zeitschriftentitel:
PLoS Comput Biol 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e1003210 
Sprache:
eng 
Print-ISSN:
1553-734X 
TUM Einrichtung:
Kinderklinik und Poliklinik