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- Document type:
- Journal Article; Article
- Author(s):
- Ellerbroek, Victoria; Warncke, Katharina; Köhle, Julia; Bonfig, Walter
- Title:
- A levothyroxine dose recommendation for the treatment of children and adolescents with autoimmune thyroiditis induced hypothyroidism.
- Abstract:
- To determine a levothyroxine (T4) dose recommendation for the treatment of autoimmune thyroiditis (AIT)-induced hypothyroidism.T4 doses in 75 children and adolescents with newly diagnosed AIT were prospectively collected and compared to T4 doses of patients with congenital hypothyroidism (CH, n=22). Results: Sixty-four patients with AIT and 22 patients with CH were included in the analysis. The thyroid-stimulating hormone declined significantly from 25.8 ± 50.1 to 2.1 ± 1.5 ?IU/mL (AIT group; p<0.01) and from 338.7 ± 380.7 to 1.9 ± 1.6 ?IU/mL (CH group; p<0.01). The required T4 dose for patients with AIT was 1.5 ± 0.5 ?g/kg per day (>= 6 to <10 years: 2.0 ± 0.4 ?g T4/kg per day; >= 10 to <12 years: 1.6 ± 0.4 ?g T4/kg per day; >= 12 to <14 years: 1.5 ± 0.6 ?g T4/kg per day; >= 14 years: 1.4 ± 0.6 ?g T4/kg per day). It deviated significantly from the CH patients' mean T4 dose of 2.8 ± 0.7 ?g T4/kg per day, p<0.01. CH patients with athyreosis required an average dose of 3.1 ± 0.5 ?g T4/kg per day; patients with ectopia, 2.6 ± 0.7 ?g T4/kg per day; and patients with dyshormonogenesis, 2.5 ± 0.6 ?g T4/kg per day. Conclusion: Juvenile patients with AIT require significantly lower T4 doses than patients with CH.
- Journal title abbreviation:
- J Pediatr Endocrinol Metab
- Year:
- 2013
- Journal volume:
- 26
- Journal issue:
- 11-12
- Pages contribution:
- 1023-8
- Language:
- eng
- Fulltext / DOI:
- doi:10.1515/jpem-2013-0038
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/23751387
- Print-ISSN:
- 0334-018X
- TUM Institution:
- Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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