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- Dokumenttyp:
- Journal Article
- Autor(en):
- Fleury, Lauren M; Wilson, Erin E; Vogt, Monika; Fan, Tiffany J; Oliver, Allen G; Ashfeld, Brandon L
- Titel:
- Amine-free approach toward N-toluenesulfonyl amidine construction: a phosphite-mediated Beckmann-like coupling of oximes and p-toluenesulfonyl azide.
- Abstract:
- Atom hopping: A chlorophosphite-mediated Beckmann ligation of oximes and p-toluenesulfonyl azide gives access to N-sulfonyl phosphoramidines in good to excellent yields. The reaction proceeds under exceptionally mild conditions and constitutes a bioorthogonal approach toward amidines by avoiding the use of amines and transition-metal catalysts. dmp-ol=3,3-dimethylpropanediol.
- Zeitschriftentitel:
- Angew Chem Int Ed Engl
- Jahr:
- 2013
- Band / Volume:
- 52
- Heft / Issue:
- 44
- Seitenangaben Beitrag:
- 11589-93
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1002/anie.201305141
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/24038711
- Print-ISSN:
- 1433-7851
- TUM Einrichtung:
- Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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