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Dokumenttyp:
journal article 
Autor(en):
Sun, Xutong; Sharma, Shruti; Fratz, Sohrab; Kumar, Sanjiv; Rafikov, Ruslan; Aggarwal, Saurabh; Rafikova, Olga; Lu, Qing; Burns, Tantiana; Dasarathy, Sridevi; Wright, Johnny; Schreiber, Christian; Radman, Monique; Fineman, Jeffrey R; Black, Stephen M 
Titel:
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. 
Abstract:
The mitochondrial dysfunction in our lamb model of congenital heart disease with increased pulmonary blood flow (PBF) (Shunt) is associated with disrupted carnitine metabolism. Our recent studies have also shown that asymmetric dimethylarginine (ADMA) levels are increased in Shunt lambs and ADMA increases the nitration of mitochondrial proteins in lamb pulmonary arterial endothelial cells (PAEC) in a nitric oxide synthase (NOS)-dependent manner. Thus, we determined whether there was a mechanisti...    »
 
Zeitschriftentitel:
Antioxid Redox Signal 
Jahr:
2013 
Band / Volume:
18 
Heft / Issue:
14 
Seitenangaben Beitrag:
1739-52 
Sprache:
eng 
Print-ISSN:
1523-0864 
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler