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Document type:
journal article 
Author(s):
Schnaiter, Andrea; Paschka, Peter; Rossi, Marianna; Zenz, Thorsten; Bühler, Andreas; Winkler, Dirk; Cazzola, Mario; Döhner, Konstanze; Edelmann, Jennifer; Mertens, Daniel; Kless, Sabrina; Mack, Silja; Busch, Raymonde; Hallek, Michael; Döhner, Hartmut; Stilgenbauer, Stephan 
Title:
NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. 
Abstract:
We studied the incidences, associations, and prognostic roles of NOTCH1 and SF3B1 mutations (NOTCH1(mut), SF3B1(mut)) as compared with TP53(mut) in fludarabine-refractory chronic lymphocytic leukemia (CLL) patients treated with alemtuzumab in the CLL2H trial. We found NOTCH1(mut), SF3B1(mut), and TP53(mut) in 13.4%, 17.5%, and 37.4% of patients, respectively. NOTCH1(mut) and SF3B1(mut) were mutually exclusive, whereas TP53(mut) were evenly distributed within both subgroups. Apart from correlatio...    »
 
Journal title abbreviation:
Blood 
Year:
2013 
Journal volume:
122 
Journal issue:
Pages contribution:
1266-70 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie