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Document type:
journal article 
Author(s):
Gewies, Andreas; Castineiras-Vilarino, Mercedes; Ferch, Uta; Jährling, Nina; Heinrich, Katja; Hoeckendorf, Ulrike; Przemeck, Gerhard K H; Munding, Matthias; Groß, Olaf; Schroeder, Timm; Horsch, Marion; Karran, E Loraine; Majid, Aneela; Antonowicz, Stefan; Beckers, Johannes; Hrabé de Angelis, Martin; Dodt, Hans-Ulrich; Peschel, Christian; Förster, Irmgard; Dyer, Martin J S; Ruland, Jürgen 
Title:
Prdm6 is essential for cardiovascular development in vivo. 
Abstract:
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2013 
Journal volume:
Journal issue:
11 
Pages contribution:
e81833 
Language:
eng 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; III. Medizinische Klinik und Poliklinik