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Dokumenttyp:
journal article 
Autor(en):
Burdach, S; Kolb, HJ 
Titel:
The vigor of defense against non-self: potential superiority of allorestricted T cells in immunotherapy of cancer? 
Abstract:
Men and sharks are both jawed vertebrates at the top of the food chain. Sharks are the first extant to develop adaptive immunity preserved to man throughout jawed vertebrates. We hypothesize here, that T cell receptor/major histocompatibility complex (TCR/MHC) interactions developed as the defense mechanism of carnivors against takeover by their victims' cells derived pathogens. Germline encoded TCR segments have been conserved in evolution, providing the MHC bias of TCR. Ancestor genes of MHC p...    »
 
Zeitschriftentitel:
Front Oncol 
Jahr:
2013 
Band / Volume:
Seitenangaben Beitrag:
100 
Sprache:
eng 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik