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Dokumenttyp:
journal article 
Autor(en):
Reichert, Maximilian; Takano, Shigetsugu; von Burstin, Johannes; Kim, Sang-Bae; Lee, Ju-Seog; Ihida-Stansbury, Kaori; Hahn, Christopher; Heeg, Steffen; Schneider, Günter; Rhim, Andrew D; Stanger, Ben Z; Rustgi, Anil K 
Titel:
The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. 
Abstract:
Pancreatic exocrine cell plasticity can be observed during development, pancreatitis with subsequent regeneration, and also transformation. For example, acinar-ductal metaplasia (ADM) occurs during acute pancreatitis and might be viewed as a prelude to pancreatic intraepithelial neoplasia (PanIN) and pancreatic ductal adenocarcinoma (PDAC) development. To elucidate regulatory processes that overlap ductal development, ADM, and the progression of normal cells to PanIN lesions, we undertook a syst...    »
 
Zeitschriftentitel:
Genes Dev 
Jahr:
2013 
Band / Volume:
27 
Heft / Issue:
Seitenangaben Beitrag:
288-300 
Sprache:
eng 
Print-ISSN:
0890-9369 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik