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Dokumenttyp:
journal article 
Autor(en):
Kleinschnitz, C; Kraft, P; Dreykluft, A; Hagedorn, I; Göbel, K; Schuhmann, MK; Langhauser, F; Helluy, X; Schwarz, T; Bittner, S; Mayer, CT; Brede, M; Varallyay, C; Pham, M; Bendszus, M; Jakob, P; Magnus, T; Meuth, SG; Iwakura, Y; Zernecke, A; Sparwasser, T; Nieswandt, B; Stoll, G; Wiendl, H 
Titel:
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. 
Abstract:
We have recently identified T cells as important mediators of ischemic brain damage, but the contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)-positive regulatory T cells (Tregs) are generally regarded as prototypic anti-inflammatory cells that maintain immune tolerance and counteract tissue damage in a variety of immune-mediated disorders. In the present study, we examined the role of Tregs after experimental brain ischemia/reperfusion injury. Selective depletion...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2013 
Band / Volume:
121 
Heft / Issue:
Seitenangaben Beitrag:
679-91 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
Klinik für Gefäßchirurgie