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Dokumenttyp:
journal article 
Autor(en):
French, Juliet D; Ghoussaini, Maya; Edwards, Stacey L; Meyer, Kerstin B; Michailidou, Kyriaki; Ahmed, Shahana; Khan, Sofia; Maranian, Mel J; O'Reilly, Martin; Hillman, Kristine M; Betts, Joshua A; Carroll, Thomas; Bailey, Peter J; Dicks, Ed; Beesley, Jonathan; Tyrer, Jonathan; Maia, Ana-Teresa; Beck, Andrew; Knoblauch, Nicholas W; Chen, Constance; Kraft, Peter; Barnes, Daniel; González-Neira, Anna; Alonso, M Rosario; Herrero, Daniel; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini...    »
 
Titel:
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. 
Abstract:
Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causative variant rs554219 increases risk of breast cancer, reduces both binding of ELK4 transcription factor and luciferase activity in reporter assays, and may be associated with low cyclin D1 protein levels i...    »
 
Zeitschriftentitel:
Am J Hum Genet 
Jahr:
2013 
Band / Volume:
92 
Heft / Issue:
Seitenangaben Beitrag:
489-503 
Sprache:
eng 
Print-ISSN:
0002-9297 
TUM Einrichtung:
Frauenklinik und Poliklinik