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Document type:
journal article 
Author(s):
Vetter, Alexandra; Virdi, Kulpreet S; Espenlaub, Sigrid; Rödl, Wolfgang; Wagner, Ernst; Holm, Per S; Scheu, Christina; Kreppel, Florian; Spitzweg, Christine; Ogris, Manfred 
Title:
Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF receptor. 
Abstract:
Adenovirus type 5 (Ad) is an efficient gene vector with high gene transduction potential, but its efficiency depends on its native cell receptors coxsackie- and adenovirus receptor (CAR) for cell attachment and ?(v)?(3/5) integrins for internalization. To enable transduction of CAR negative cancer cell lines, we have coated the negatively charged Ad by noncovalent charge interaction with cationic PAMAM (polyamidoamine) dendrimers. The specificity for tumor cell infection was increased by targeti...    »
 
Journal title abbreviation:
Mol Pharm 
Year:
2013 
Journal volume:
10 
Journal issue:
Pages contribution:
606-18 
Language:
eng 
Print-ISSN:
1543-8384 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung