User: Guest  Login
Document type:
journal article 
Author(s):
Grünwald, GK; Vetter, A; Klutz, K; Willhauck, MJ; Schwenk, N; Senekowitsch-Schmidtke, R; Schwaiger, M; Zach, C; Wagner, E; Göke, B; Holm, PS; Ogris, M; Spitzweg, C 
Title:
Systemic image-guided liver cancer radiovirotherapy using dendrimer-coated adenovirus encoding the sodium iodide symporter as theranostic gene. 
Abstract:
Currently, major limitations for the clinical application of adenovirus-mediated gene therapy are high prevalence of neutralizing antibodies, widespread expression of the coxsackie-adenovirus receptor (CAR), and adenovirus sequestration by the liver. In the current study, we used the sodium iodide symporter (NIS) as a theranostic gene to investigate whether coating of adenovirus with synthetic dendrimers could be useful to overcome these hurdles in order to develop adenoviral vectors for combina...    »
 
Journal title abbreviation:
J Nucl Med 
Year:
2013 
Journal volume:
54 
Journal issue:
Pages contribution:
1450-7 
Language:
eng 
Print-ISSN:
0161-5505 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; Institut für experimentelle Onkologie und Therapieforschung