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Document type:
journal article 
Author(s):
Mantwill, K; Naumann, U; Seznec, J; Girbinger, V; Lage, H; Surowiak, P; Beier, D; Mittelbronn, M; Schlegel, J; Holm, PS 
Title:
YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells. 
Abstract:
The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence. In brain CSC, the PI3-K/AKT and the RAS/mitogen activated protein kinase (MAPK) pathways are found to be activated. In consequence, the human transcription factor YB-1, knowing to be responsible for the emergence of drug resistance and driving adenoviral replication, is phosphorylated and activated. With this knowledge, YB-...    »
 
Journal title abbreviation:
J Transl Med 
Year:
2013 
Journal volume:
11 
Pages contribution:
216 
Language:
eng 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung; Institut für Allgemeine Pathologie und pathologische Anatomie