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Dokumenttyp:
journal article 
Autor(en):
Neff, F; Flores-Dominguez, D; Ryan, DP; Horsch, M; Schröder, S; Adler, T; Afonso, LC; Aguilar-Pimentel, JA; Becker, L; Garrett, L; Hans, W; Hettich, MM; Holtmeier, R; Hölter, SM; Moreth, K; Prehn, C; Puk, O; Rácz, I; Rathkolb, B; Rozman, J; Naton, B; Ordemann, R; Adamski, J; Beckers, J; Bekeredjian, R; Busch, DH; Ehninger, G; Graw, J; Höfler, H; Klingenspor, M; Klopstock, T; Ollert, M; Stypmann, J; Wolf, E; Wurst, W; Zimmer, A; Fuchs, H; Gailus-Durner, V; Hrabe de Angelis, M; Ehninger, D 
Titel:
Rapamycin extends murine lifespan but has limited effects on aging. 
Abstract:
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the FDA-approved mTOR inhibitor rapamycin represented the first demonstration of pharmacological extension of maximal lifespan in mammals. Longevity effects of rapamycin may,...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2013 
Band / Volume:
123 
Heft / Issue:
Seitenangaben Beitrag:
3272-91 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Molekulare Allergologie und Umweltforschung; Institut für Allgemeine Pathologie und pathologische Anatomie; Klinik und Poliklinik für Dermatologie und Allergologie