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Dokumenttyp:
journal article 
Autor(en):
Walstab, J; Krüger, D; Stark, T; Hofmann, T; Demir, I E; Ceyhan, G O; Feistel, B; Schemann, M; Niesler, B 
Titel:
Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. 
Abstract:
Beneficial effects of ginger in the treatment of gastrointestinal (GI) problems and chemotherapy-induced nausea and vomiting are well accepted. In rodents, the action of ginger seems to be mediated by the inhibition of 5-HT3 receptors, which are established targets to combat emesis and irritable bowel syndrome.Heterologously expressed human 5-HT3 A or 5-HT3 AB receptors were characterized by means of Ca(2+) influx studies using HEK293 cells. Complementing Ca(2+) measurements in Fluo-4-AM-stained...    »
 
Zeitschriftentitel:
Neurogastroenterol Motil 
Jahr:
2013 
Band / Volume:
25 
Heft / Issue:
Seitenangaben Beitrag:
439-47, e302 
Sprache:
eng 
Print-ISSN:
1350-1925 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik