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Dokumenttyp:
journal article 
Autor(en):
Friedrich, Teresa; Richter, Birgit; Gaiser, Timo; Weiss, Christel; Janssen, Klaus-Peter; Einwächter, Henrik; Schmid, Roland M; Ebert, Matthias P A; Burgermeister, Elke 
Titel:
Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis. 
Abstract:
Caveolin-1 (Cav1), a scaffold protein of membrane caveolae and coactivator of peroxisome proliferator-activated receptor gamma (PPARg), inhibits oncogenic signaling through Ras and wingless. However, the in vivo role of Cav1 in colorectal cancer (CRC) remained unknown. To test whether loss of Cav1 accelerates tumorigenesis, we generated a novel mouse model of CRC by crossing C57BL/6 Apc(min/+) with B6129 Cav1 knockout (Cav1-/-) mice. Apc(min/+) Cav1-/- mice developed large, microinvasive and vas...    »
 
Zeitschriftentitel:
Carcinogenesis 
Jahr:
2013 
Band / Volume:
34 
Heft / Issue:
Seitenangaben Beitrag:
2109-18 
Sprache:
eng 
Print-ISSN:
0143-3334 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik