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Document type:
journal article 
Author(s):
Thai, To-Ha; Patterson, Heide Christine; Pham, Duc-Hung; Kis-Toth, Katalin; Kaminski, Denise A; Tsokos, George C 
Title:
Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouse. 
Abstract:
MicroRNA-155 (miR-155) regulates antibody responses and subsequent B-cell effector functions to exogenous antigens. However, the role of miR-155 in systemic autoimmunity is not known. Using the death receptor deficient (Fas(lpr)) lupus-prone mouse, we show here that ablation of miR-155 reduced autoantibody responses accompanied by a decrease in serum IgG but not IgM anti-dsDNA antibodies and a reduction of kidney inflammation. MiR-155 deletion in Fas(lpr) B cells restored the reduced SH2 domain-...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2013 
Journal volume:
110 
Journal issue:
50 
Pages contribution:
20194-9 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie