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Dokumenttyp:
journal article 
Autor(en):
Eser, S; Reiff, N; Messer, M; Seidler, B; Gottschalk, K; Dobler, M; Hieber, M; Arbeiter, A; Klein, S; Kong, B; Michalski, CW; Schlitter, AM; Esposito, I; Kind, AJ; Rad, L; Schnieke, AE; Baccarini, M; Alessi, DR; Rad, R; Schmid, RM; Schneider, G; Saur, D 
Titel:
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. 
Abstract:
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited. We show that cell-autonomous phosphoinositide 3-kinase (PI3K) and 3-phosphoinositide-dependent protein kinase 1 (PDK1), but not Craf, are key effectors of oncogenic Kras in the pancreas, mediating cell plasticity, acinar-to-ductal metaplasia (ADM), and pancreatic ductal adenocarcinoma (PDAC) formation. This contrasts with Kras-driven non-small cell lung cancer, where...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2013 
Band / Volume:
23 
Heft / Issue:
Seitenangaben Beitrag:
406-20 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; Chirurgiesche Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie