User: Guest  Login
Document type:
journal article 
Author(s):
Müller, Martina A; Opfer, Jan; Brunie, Leonora; Volkhardt, Lilli A; Sinner, Eva-Kathrin; Boettiger, David; Bochen, Alexander; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute 
Title:
The glycophorin A transmembrane sequence within integrin ?v?3 creates a non-signaling integrin with low basal affinity that is strongly adhesive under force. 
Abstract:
Integrin heterodimeric cell adhesion and signaling receptors bind ligands of the extracellular matrix and relay signals bidirectionally across cell membranes. Thereby, integrins adopt multiple conformational and functional states that control ligand binding affinity and linkage to cytosolic/cytoskeletal proteins. Here, we designed an integrin chimera encompassing the strongly dimerizing transmembrane domain (TMD) of glycophorin A (GpA) in the context of the otherwise unaltered integrin ?v?3. We...    »
 
Journal title abbreviation:
J Mol Biol 
Year:
2013 
Journal volume:
425 
Journal issue:
16 
Pages contribution:
2988-3006 
Language:
eng 
Print-ISSN:
0022-2836 
TUM Institution:
Frauenklinik und Poliklinik