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Document type:
journal article 
Author(s):
Kruglov, AA; Grivennikov, SI; Kuprash, DV; Winsauer, C; Prepens, S; Seleznik, GM; Eberl, G; Littman, DR; Heikenwalder, M; Tumanov, AV; Nedospasov, SA 
Title:
Nonredundant function of soluble LT?3 produced by innate lymphoid cells in intestinal homeostasis. 
Abstract:
Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However, mechanisms regulating IgA induction are not completely defined. We show that soluble lymphotoxin ? (sLT?3) produced by ROR?t(+) innate lymphoid cells (ILCs) controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut. By contrast, membrane-bound lymphotoxin ? (LT?1?2) produced by ROR?t(+) ILCs is cr...    »
 
Journal title abbreviation:
Science 
Year:
2013 
Journal volume:
342 
Journal issue:
6163 
Pages contribution:
1243-6 
Language:
eng 
Print-ISSN:
0036-8075 
TUM Institution:
Institut für Virologie